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1995-02-08
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AIDS Daily Summary
February 8, 1995
The Centers for Disease Control and Prevention (CDC) National AIDS
Clearinghouse makes available the following information as a public
service only. Providing this information does not constitute endorsement
by the CDC, the CDC Clearinghouse, or any other organization. Reproduction
of this text is encouraged; however, copies may not be sold, and the CDC
Clearinghouse should be cited as the source of this information.
Copyright 1995, Information, Inc., Bethesda, MD
************************************************************
"Settlement Reached in AIDS Suit"
"Who Will Care for Children when Parents Die of AIDS?"
"Parole Denied to Top Figure in French AIDS Scandal"
"Growing AIDS Epidemic Becomes More Diverse"
"Chronicle"
"Across the USA: Mississippi/New Mexico"
"HIV Population Dynamics in Vivo: Implications for Genetic
Variation, Pathogenesis, and Therapy"
"Drug Malabsorption and Resistant Tuberculosis in HIV-Infected
Patients"
"Danish Haemophiliacs Court Case Nears Conclusion"
"Silence=Stigma"
************************************************************
"Settlement Reached in AIDS Suit"
Philadelphia Inquirer (02/08/95) P. B2; Vedantam, Shankar
An undisclosed settlement has been reached in the AIDS
discrimination lawsuit filed by surgeon Paul Scoles against Mercy
Health Corp., with both sides claiming vindication. The
settlement came after a federal judge's ruling in December that
Mercy Health did not discriminate against Scoles, who is
HIV-positive, when it required him to disclose his status to his
patients before treating them. Scoles and his lawyers claimed
victory for making hospitals in the United States "change their
behavior" toward doctors who are infected with HIV. Mercy Health
said that because AIDS meant "nearly certain death," it was
impossible to hide risks of infection from patients, no matter
how small such risks may be. In 1992, Scoles charged that Mercy
Health suspended his surgical privileges and ruined his practice
after he revealed he was HIV-positive. He claimed that
Misericordia Hospital, which is operated by Mercy Health, sent
more than 1,000 letters to his former patients informing them
that he was infected.
"Who Will Care for Children when Parents Die of AIDS?"
Philadelphia Inquirer (02/08/95) P. H1; Martin, Antoinette
Since late last summer, a series of public service announcements
by the National Council for Adoption (NCFA) has urged parents
with AIDS to arrange adoptions for their children before they
die. One of the ads says, "AIDS. Kids. If you have both, maybe
it's time to take a closer look at adoption." The ads have been
on television and radio stations in cities including
Philadelphia, New York City, Detroit, and San Francisco. "We are
targeting areas where the AIDS epidemic is prevalent," says
William Pierce, president of the Washington, D.C., non-profit
group. Pierce says that hundreds of calls--from people with
AIDS, support groups, and people wanting to adopt--have flooded
the phone lines since the ads began airing last spring in the
Washington area. There have been no negative responses. So far,
64 children have been adopted as a result of the national
campaign. The number of children in the United States that have
been orphaned by AIDS is estimated to be about 35,000. Health
officials project that by the year 2000, there will be between
70,000 and 125,000 AIDS orphans, says Pierce.
"Parole Denied to Top Figure in French AIDS Scandal"
Philadelphia Inquirer (02/08/95) P. A6
On Tuesday, a Paris court rejected a bid for parole by Dr.
Michael Garretta, the head of France's state-run blood bank
during the mid-1980s. It was during that period that more than
1,000 hemophiliacs became HIV-infected from tainted blood as
officials used up stocks to save money rather than import
virus-free products. In making its decision, the three-judge
panel cited the "exceptional extent of damages" in the scandal,
and noted that "parole...is not an automatic right of the
convicted." Garretta was jailed in October 1992 for "fraud in
the quality of merchandise."
"Growing AIDS Epidemic Becomes More Diverse"
Boston Globe (02/07/95) P. 32; Walsh, Pamela M.
Although AIDS was once thought of as a disease of only gay men
and intravenous drug users, recent data from the Centers for
Disease Control and Prevention show that it is now moving into
the mainstream. A study at the Living Center, a resource center
in Boston for HIV-infected people, identified a shift toward more
women and minorities. In 1992, 17 percent of the center's
members were black and Hispanic males, but now they make up 32
percent of the 1,000 members. Hispanic women make up 25 percent
of the center's female membership, whereas in 1992 there were
none. While there were 12 heterosexual members three years ago,
there were 40 in 1994.
"Chronicle"
New York Times (02/08/95) P. B4; Steinhauer, Jennifer
The feathered white wings used in the Broadway production "Angels
in America" will be donated the AIDS Resource Center's "Valentine
Auction," to be held Monday in SoHo, New York. Works donated by
artists Louise Bourgeois and Jenny Holzer and the estate of the
photographer Robert Mapplethorpe will also be sold. Proceeds
from the auction will benefit the AIDS Resource Center, which
provides housing for homeless people with AIDS.
"Across the USA: Mississippi/New Mexico"
USA Today (02/07/95) P. 11A
Jury selection began on Tuesday in Laurel, Miss., for the murder
trial of 16-year-old Marvin McClendon, who is accused of killing
two gay men last October. According to his lawyer, McClendon
shot the unarmed men to protect himself from rape and possible
exposure to AIDS. In New Mexico, lawmakers are considering a
bill to permit state health workers distribute clean needles to
drug addicts. The measure, which is intended to stem the spread
of AIDS and other diseases, would use $220,000 to initiate pilot
programs in two counties.
"HIV Population Dynamics in Vivo: Implications for Genetic
Variation, Pathogenesis, and Therapy"
Science (01/27/95) Vol. 267, No. 5197, P. 483; Coffin, John M.
Several recent reports show that the long, clinically latent
phase characteristic of human HIV infection is not a period of
viral inactivity, but an active process in which cells are being
infected and dying at a high rate and in large numbers. John M.
Coffin of the Department of Molecular Biology and Microbiology at
Tufts University School of Medicine used these results to develop
a simple, steady-state model in which infection, cell death, and
cell replacement are in balance. The findings suggest that the
unique feature of HIV is the exceptionally high number of
replication cycles that occur during infection of a single
person. A consequence of rapid turnover is the development of
genetic variation, which can build up populations of HIV strains
resistant to antiviral drugs. Coffin also notes that
understanding the dynamics of the latent period may lead to ideas
for new therapeutic strategies.
"Drug Malabsorption and Resistant Tuberculosis in HIV-Infected
Patients"
New England Journal of Medicine (02/02/95) Vol. 332, No. 5, P.
336; Patel, Kalpana B.; Belmonte, Romelle; Crowe, Helen M.
In a letter to the editor published in the New England Journal of
Medicine, Patel et al. describe their experiences in caring for
two HIV-infected patients who relapsed into drug-resistant
isolates of Mycobacterium tuberculosis (TB). The relapse is
presumed to be because of subtherapeutic drug levels caused by
malabsorption. The first patient received isoniazid, rifampin,
and pyrazinamide daily for ileocecal and pulmonary TB. After
four months of observed therapy, he was found to have a new
cavitary pulmonary lesion. Sputum cultures grew M. tuberculosis
that was resistant to rifampin, but still sensitive to isoniazid,
pyrazinamide, ethambutol, and streptomycin. The second patient,
diagnosed with pulmonary TB, received rifampin, pyrazinamide, and
ethambutol daily under direct supervision in a homeless shelter.
A new right-upper-lobe infiltrate appeared after 10 months. An
isolate of sputum was resistant to both isoniazid and rifampin,
but still sensitive to pyrazinamide, ethambutol, and
streptomycin. The cases illustrate that drug malabsorption may
contribute to the emergence of drug resistance, as some
researchers have theorized. The researchers suggest routine
screening of antimycobacterial-drug levels in HIV-infected
patients with TB, especially those with advanced HIV disease.
"Danish Haemophiliacs Court Case Nears Conclusion"
Lancet (02/04/95) Vol. 345, No. 8945, P. 313; Skovmand, Kaare
On Feb. 9, a Danish High Court will determine whether the
National Board of Health, the Ministry of Health, and factor VIII
maker Novo Nordisk are liable for the HIV-infection of eight
hemophiliacs. They are being sued by the Danish Haemophiliacs
Association, which claims that the patients were infected through
factor VIII received after Jan. 1, 1985. The association claims
that by Jan. 1, 1985, the authorities and the producer should
have been aware of the risk of HIV-transmission via factor VIII.
To support the claim that action to prevent HIV transmission
through factor VIII products was taken late, the prosecution
presented evidence of very poor communication among the
authorities in 1985. The defendants claim that their actions
were based on what they thought to be right in light of existing
knowledge at the time. The trial has added to the bad publicity
Novo Nordisk received in 1988 when it was fined Dkr15,000 for
having marketed products prepared from blood not screened for
HIV. A total of 90 Danish hemophiliacs became HIV-infected
during the 1980s through therapy with factor VIII.
"Silence=Stigma"
Advocate (02/07/95) No. 674, P. 31; Gallagher, John
Many AIDS activists say that the stigma attached to AIDS will
continue unless individuals, especially famous ones, acknowledge
their illness. A. Cornelius Baker, director of public policy and
education at the National Association for People With AIDS, said
that AIDS is more likely to be hidden if the person who has it is
a gay man, particularly if he is a celebrity. For example,
journalist Randy Shilts, who died in 1994, has been the object of
scorn because he only revealed his illness after his health
declined significantly. Despite Shilts' status as a prominent
historian of the AIDS epidemic and perhaps the first openly gay
reporter in mainstream media, he remained silent for several
years about being HIV-infected. Most often, however, the AIDS
closet involves the suppression of AIDS as the cause of death in
tributes and obituary notices. Often survivors avoid naming AIDS
as the cause of death, using instead a kind of code where young
men die from "long-term illness" or "heart failure." Although
activists hope for more openness, they understand why many people
do not choose it. "There has to be a respect for privacy," said
Baker. "You have to allow people to die in the fashion they
choose."